Endocrine Abstracts

Objective: Diabetes and obesity cause functional hypogonadism (FH) and impair sperm quality. Testosterone replacement therapy (TRT) improves the signs and symptoms of FH but it further deteriorates sperm quality by inhibiting the endogenous gonadal axis. The effect of glucagon-like peptide-1 receptor agonists (GLP-1-RAs) on FH is suggested to be beneficial due to weight loss. However, the effect of GLP-1 RAs on sperm quality in patients with type 2 diabetes mellitus and obesit...